Modafinil and Antidepressants

Antidepressant discontinuation syndrome can be also named abstinent syndrome, as it is a component of physical dependency syndrome. Antidepressant discontinuation syndrome includes a group of symptoms at various severity degrees. It appears after complete discontinuance of antidepressant use or reduction of its dosage after lengthy or high-dosage use of the antidepressant.

Symptoms can be both of physical and psychological (mental) nature. The beginning and course of discontinuation syndrome are limited in time and depend on the type of antidepressants and dosage that was taken before the drug use discontinuance.

Causes of withdrawal antidepressants

Abstinent syndrome appears as a result of the organism’s lack or shortage of a substance that caused dependency. Syndrome develops according to the following scheme: the organism tries to reproduce functional conditions, which have been developing in the presence of the psychoactive substance. For instance, vascular tone changes, heart rate frequency increases, more mucus in the gastrointestinal tract organs is produced, serotonin release in the brain decreases, and so on. For the body, this condition is unusual and it puts all of its efforts to increase vascular tone, accelerate pill action, causing somatic, vegetative, and mental reactions.

Withdrawal symptoms antidepressants

Symptom complex depends upon the type of antidepressant and can have various natures:

-Discontinuation syndrome can be complicated by seizures;


-Feeling of anxiety;


-Decrease of sensory ability;



-Increase of arterial tension, and so on.

In psychoactive substance discontinuation, specialists outline prodrome periods, when the nervous system dysfunction signs are most evident – irritability, tearfulness, limb tremor, and other. Then, the sharp period passes and changes into the clinical abstinence stage, with manifestations individual for each separate patient.

Diagnosis and treatment of withdrawal antidepressants

Of course, the patient can understand that they start to experience discontinuation syndrome, but only a specialist can appraise the severity of their condition and prescribe optimal therapy. There are certain laboratory and psychodiagnostic tests, which demonstrate the degree of intensity of pathological processes. In severe cases, stationary treatment is possible.

In order to reduce the severity of abstinent syndrome, the patient goes through a therapy of infusion, detoxification, and metabolism improvement. The doctor can prescribe vitamins, nootropics, tranquillizers, anticonvulsive drugs, soporifics, corticosteroids, and other medicines.

Since in the periods of antidepressant discontinuation and appearance of abstinent syndrome, the person can experience mood changes, loss of strength, and nervousness, there are medicines prescribed for the easing of this condition.

Modafinil drug causes invigorating effect, improves attention concentration and removes apathy. It is noted that when taking an Modafinil dosage, energetic tone increases, the person stops feeling sleepiness and fatigue. Therefore, even healthy people are using Modafinil pills drug in situation, when they have to continue working and refuse from the time for rest.

Daily Modafinil dosage depends upon individual organism receptiveness towards the drug. In order to maintain cheerfulness during the day, it is possible to take Modafinil 100 mg in the morning. If abstinent syndrome is heavily tolerated, it is possible to take another Modafinil 100 mg tablet in the afternoon. Depending on the organism’s reaction, daily Modafinil drug dose is 200-400 mg. Generic Modafinil 400 mg is the highest Modafinil dose that you can take during 24 hours. Exceeding the highest daily dose of Modafinil 400 mg can lead to the appearance of Modafinil side effectrs and overdose, as well.

Modafinil is a medicine that has a wide range of effect. Antidepressant discontinuation syndrome can be treated by Modafinil. If you want to learn more about Modafinil medicine, you should take a look at this article today.